Preview: 1up
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Rabies is a nasty disease. If contracted by a human (generally through an animal bite), it can be virtually undetectable for up to three months. Once symptoms start manifesting themselves--such as aggression and hallucinations--it's generally too late; death almost invariably follows in as little as two days from the first manifestation of symptoms.
In our world of SARS and West Nile and bird flu, where affordable air travel transports disease with a speed and breadth never before seen, the idea of a drug-resistant, fast-spreading rabies virus is frighteningly plausible. Frightening enough, certainly, to serve as the premise of a survival-horror game.