Well solution for me anyway...
I had never played Stalker, so decided to finally install it after purchasing it a year ago. Installed Stalker patched to v1.00005 then to v1.00006. I'm also using the latest official drivers (174.74).
Start the game goes there the regular
PR crap. Once I made it to the actual game menu it flickered from the menu to a screen with red/blue/white boxes and I couldn't manipulate anything in the menu. I had to switch back out to my desktop then kill the process. I don't have any crazy settings under my Nvidia control panel so I knew that wasn't it. However, did some searching found a few people w/ the same issue, but others did not have it.
To make a long story short the solution is to alter the resolution at the end of the 'user.ltx' to whatever you want it to be. BTW, I didn't figure this out on my own found it on another site by a user named 'Skinner'.