Weird, I didn’t get a notification of a reply.
Anyway, the file is just a temp file. It should be stored wherever it is configured to (and used to be in an older version of GuidePlus+), but is now stored in C:\ no matter what you set it to. This patch doesn’t remove the actual file, it patches the location in the DLL so that GuidePlus+ puts the file where you tell (eg a TEMP directory) it to instead of C:\.